Nov 03, 2016

SNAC-tag for sequence-specific chemical protein cleavage Mar 25, 2019 Non-cleavable Linker - Creative Biolabs Non-cleavable linkers have no obvious drug release mechanism and ADCs prepared by this strategy relies on the complete lysosomal proteolytic degradation of the antibody after internalization to release the payload drug. Through this degradation, the non-cleavable linker carrying the drug will also be coupled with the conjugation amino acid from

Mar 29, 2020 · Catch and Release: A new cleavable linker based on secondary amino alcohols is reported for application in peptide discovery. The linker is easily incorporated into peptides during on‐resin synthesis and is shown to be rapidly cleaved in the presence of NaIO 4. Peptide‐library and cell‐based experiments demonstrate that this linker enables the recovery of hit sequences after affinity capture.

Traceless and multifunctional linkers for the generation Jun 01, 2004

Relatively few cleavable linkers are available for DNA-directed synthesis and most often they leave an amino group at the organic molecule. Here we have extended the application of aryltriazenes as traceless linkers for DNA-directed synthesis. After reaction of one building block with a building block at another DNA strand the triazene linker

Site-specific chemical modification of antibody fragments using traceless cleavable linkers. Gonçalo J L Bernardes 1,2,3, Martina Steiner 1, Isabelle Hartmann 1, Dario Neri 1 & Delivery and Release of Small-Molecule Probes in Here, we describe cleavable linkers designed for the traceless release of chemical cargo from MPPs following mitochondrial transit. The cleavage kinetics of a number of disulfides were investigated using a fluorescent reporter system in order to optimize linker stability for mitochondrial release. The stability of mono- and disubstituted Cleavable vs. Non-Cleavable Linkers in Antibody-Drug Dec 19, 2019 Cleavable linkers in chemical biology - ScienceDirect